In November 2001, Blunt made her professional debut opposite Judi Dench in Sir Peter Hall's production of the play The Royal Family.
Hailed by critics for her performance, she was named "Best Newcomer" by The Evening Standard.
In 2009, Blunt played Queen Victoria in The Young Victoria, directed by Jean-Marc Vallée and written by Julian Fellowes.
She also starred in the Toby Spanton-directed short film Curiosity.
She went on to perform as Eugenie in Nicholas Wright's Vincent in Brixton at the National Theatre, and as Juliet in Indhu Rubasingham's production of Romeo and Juliet at Chichester Festival Theatre, both in 2002.
In 2003, Blunt made her screen debut in the British television drama Boudica, about the life of the ancient Celtic warrior-queen who fought the Romans.
Blunt received her fourth and fifth Golden Globe Award nominations for her roles in the romantic comedy-drama Salmon Fishing in the Yemen (2012) and the musical fantasy Into the Woods (2014) in the Best Actress – Motion Picture Comedy or Musical category.
In 2016, Blunt starred in the fantasy-action film The Huntsman: Winter's War and The Girl on the Train, the latter based on the international best-selling novel of the same name.
2009 also saw Blunt appear in the crime caper comedy "Wild Target" with Bill Nighy and Rupert Grint.
She found commercial success for roles in the romantic science-fiction thriller The Adjustment Bureau (2011), the science-fiction action thriller Looper (2012), and the sci-fi film Edge of Tomorrow (2014).
Also that year, she briefly appeared in Disney's The Muppets, as Miss Piggy's receptionist.
She starred in the 2012 film The Five-Year Engagement, directed by Nicholas Stoller and co-starring Jason Segel.
That same year, she was praised for her performance as the 16th-century queen Catherine Howard in the two-part British television drama Henry VIII.